pentobarbital will lower the extent or effect of amiodarone by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Watch.pentobarbital will minimize the extent or outcome of cobimetinib by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated. Steer clear of coadministration. Potent or reasonable CYP3A inducers may r